Fez1/Lzts1 -deficient mice are more susceptible to N -butyl- N -(4-hydroxybutil) nitrosamine (BBN) carcinogenesis
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منابع مشابه
The interaction of arsenic and N-butyl-N-(4-hydroxybutyl)nitrosamine on urothelial carcinogenesis in mice
The bladder is an important organ for the storage of excreted water and metabolites. If metabolites with carcinogenic characteristics are present in urine, the urothelial lining of the bladder could be damaged and genetically altered. In this study, we analyzed the interaction of arsenic and N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) on mouse bladder carcinogenesis. Our previous study found th...
متن کاملN - Butyl - N - ( 4 - Hydroxybutyl ) Nitrosamine in Rats and Mice Comparison of Uroplakin Expression During Urothelial Carcinogenesis Induced
http://tpx.sagepub.com/content/27/6/645 The online version of this article can be found at: DOI: 10.1177/019262339902700606 1999 27: 645 Toxicol Pathol Cohen Kumiko Ogawa, Margaret St. John, Maria Luiza De Oliveira, Lora Arnold, Tomoyuki Shirai, Tung-Tien Sun and Samuel M. N-Butyl-N-(4-Hydroxybutyl)Nitrosamine in Rats and Mice Comparison of Uroplakin Expression During Urothelial Carcinogenesis ...
متن کاملEffects of promoters on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in the rat.
It has been shown that the occurrence of the preneoplastic lesion, papillary or nodular hyperplasia (PN hyperplasia) in rat urinary bladder induced by carcinogens is correlated with that of cancer. Therefore, the promoting effects of chemicals in two-stage bladder carcinogenesis were judged by measuring their ability to induce PN hyperplasia in rats. Male rats were given N-butyl-N-(4-hydroxybut...
متن کاملUrinary bladder tumors induced by N-butyl-N-(4-hydroxybutyl)nitrosamine in dogs.
Clinicopathological, radiological, and histological studies were performed on urinary bladder neoplasia induced by N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) in five adult beagle dogs and in ten adult mongrel dogs. Tumors of the urinary bladder developed in dogs given various daily doses of BBN p.o. for different periods. The latent period of tumor induction was 4 years in dogs receiving a dai...
متن کاملKnockout of phospholipase Cε attenuates N-butyl-N-(4-hydroxybutyl) nitrosamine-induced bladder tumorigenesis
Bladder cancer frequently shows mutational activation of the oncogene Ras, which is associated with bladder carcinogenesis. However, the signaling pathway downstream of Ras remains to be fully elucidated. N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) is able to induce bladder cancer by driving the clonal expansion of initiated cells carrying the activated form of Ras. Phospholipase Cε (PLCε) is ...
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ژورنال
عنوان ژورنال: Carcinogenesis
سال: 2008
ISSN: 1460-2180,0143-3334
DOI: 10.1093/carcin/bgn006